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KMID : 1037820170060020026
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Journal of Pain and Autonomic Disorders
2017 Volume.6 No. 2 p.26 ~ p.29
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Pure Autonomic Failure
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Cho Jeong-Hee
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Abstract
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Pure autonomic failure (PAF) is a neurodegenerative autonomic disorder characterized by widespread autonomic failure and pathological findings of Lewy bodies containing α-synuclein. Autonomic function test shows sympathetic and parasympathetic dysfunction and postganglionic sudomotor impairment. In supine position, patients with PAF have very low plasma norepinephrine. Some patients with PAF progress to central nervous system synucleinopathies. There is no specific treatment to stop progression of PAF and the main treatment of PAF is directed toward improvement of autonomic symptoms.
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KEYWORD
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Pure autonomic failure, Lewy bodies, Synucleins, Sympathetic nervous system, Parasympathetic nervous system, Norepinephrine
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